IN VITRO AND EX VIVO EVALUATION OF PRECLINICAL MODELS FOR FAP-TARGETED THERANOSTICS: DIFFERENCES AND RELEVANCE FOR RADIOTRACER EVALUATION

In vitro and ex vivo evaluation of preclinical models for FAP-targeted theranostics: differences and relevance for radiotracer evaluation

Abstract Background Fibroblast activation protein (FAP) is an attractive target for cancer theranostics.Although FAP-targeted nuclear imaging demonstrated promising clinical results, only sub-optimal results are reported for targeted radionuclide therapy (TRT).Preclinical research is crucial in selecting promising FAP-targeted radiopharmaceuticals

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